Autoimmune hepatitis in human immunodeficiency virus-infected patients: A case series and review of the literature

Table 4 Baseline characteristics at autoimmune hepatitis presentation of previously reported human immunodeficiency virus cases

No.	Sex, age (yr)	HIV status				Presentation	ANA titer	ASMA titer	Treatment	Outcome
		HIV Duration	ART duration	Viral load	CD4
1[21]	NA	NA	NA	< 48	1011	NA	1:640	1:40	P+ Z	Remission
2[21]	NA	NA	NA	< 48	456	NA	Neg	1:20	P+ Z	Remission
3[21]	NA	NA	NA	< 48	783	NA	1:40	1:320	P+ Z	Remission
4[21]	NA	NA	NA	< 48	688	Acute liver failure	1:640	1:160	LT	Relapse at 4 yr after LT
5[21]	NA	NA	NA	< 48	653	n/a	1:1280	1:20	P+ Z	Remission
6[22]	M, 54	NA	3 yr	5104	357	↑ ALT*	1:40	1:640	P+ Z	Remission
7[22]	F, 55	NA	NA	< 50	174	↑ ALT	Neg	1:40	P+ Z	Relapse
8[22]	F, 49	NA	NA	69318	286	↑ ALT	Neg	Neg	P+ Z	Died
9[22]	F, 56	NA	NA	232734	331	↑ ALT	1:40	1:20	P	Died
10[23]	M, 21	Newly diagnosed	0	7900	753	Jaundice	Neg	Neg	P	Relapse
11[23]	F, 59	n/a	7 mo	-	504	↑ ALT	Pos	Pos	P+ Z	Remission
12[24]	M, 26	3 yr	1 yr	-	NA	Jaundice	1:160	Neg	P+ Z	Relapse
13[25]	M, 40	8 yr	8 yr	ND	832	↑ ALT	Neg	1:60	P+ Z	Relapse
14[25]	F, 44	20 yr	7 yr	ND	823	Acute hepatitis*	1:640	1:180	P	Remission
15[26]	M, 52	7 yr	7	ND	641	↑ ALT	1:2560	NA	P	Remission
16[27]	F, 44	9 mo	9 mo	ND	526	↑ ALT	1:160	1:160	P+ Z	Minor flare during taper steroid
17[28]	M, 29	Newly diagnosed	0	7122	259	↑ ALT	Neg	Neg	none	Resolved spontaneously
18[28]	F, 45	2 yr	7 mo	ND	297	↑ ALT	1:640	Neg	P+Z	Remission
19[28]	F, 65	10 yr	n/a	ND	922	↑ ALT	1:160	1:320	P+Z → MMF	Flare
20[29]	M, 38	2 yr after AIH diagnosed	0	81000	216	↑ ALT	1:320	1:40	ART	ALT improved after ART initiaion
21[30]	F, -	15 yr	12 yr	ND	634	Acute hepatitis	1:20000	Neg	P	Remission
22[31]	F, 48	20 yr	NA	ND	> 250	Acute hepatitis	1:80	1:300	P	Died
23[32]	F, 23	NA	8 mo	ND	523	↑ Jaundice and ALT*	Pos	Neg	P ± Z	Remission
24[32]	F, 31	NA	7 mo	< 40	277		Pos	Neg
25[32]	F, 42	NA	10 mo	-	593		Pos	Pos
26[32]	F, 45	NA	6 mo	< 40	253		Neg	Pos
27[32]	F, 35	NA	41 mo	ND	339		Neg	Pos
28[32]	M, 39	NA	77 mo	ND	416		Neg	Pos
29[32]	F, 39	NA	4 mo	ND	357		Neg	Pos
30[32]	F, 43	NA	4 mo	ND	876		Pos	Neg
31[32]	F, 36	NA	17 mo	ND	693		Neg	Pos
32[33]	F, 42	20 yr	NA	ND	232	Acute hepatitis	1:1280	Neg	P	Remission
33[34]	F, 51	NA	11 mo	94	417	Acute liver failure	1:256	1:80	P	Died
34[35]	F, 38	13 yr	NA	6392	436	NA	1:400	Pos	B	Remission
35[36]	M, 38	2 yr	0	8072	762	Acute hepatitis	1:640	1:160	P+Z	Remission
36[37]	F, 70	32 yr	24 yr	< 50	938	Decompensated cirrhosis*	1:640	NA	P	Remission
37[38]	M, 43	13 yr	2 yr	ND	900	↑ ALT	1:160	NA	P	Remission
38[39]	F, 43	4 yr	18 mo	ND	425	Acute hepatitis	1:8000	Neg	P+Z	Flare during tapering steroid

ART: Antiretroviral therapy; B: Budesonide; M: Mycophenolate mofetil, P: Prednisolone; Z: Azathioprine; LT: Liver transplantation; NA: Not available.