Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy

Table 2 Prognostic analysis according to patients’ characteristics

Background		HR (95%CI)	P value
Age	≥ 65 yr	0.57 (0.21–1.51)	0.26
Gender	Male	1.09 (0.38–3.07)	0.87
ECOG PS	0	0.37 (0.04–2.84)	0.34
Macroscopic type	Type 4	1.51 (0.53–4.25)	0.43
Primary site	Stomach	0.27 (0.05–1.24)	0.09
Tumor histology	Undifferentiated	1.14 (0.44–2.90)	0.78
T-classification	≥ 4a	4.73 (0.62–35.7)	0.13
N-classification	≥ 3a	1.63 (0.57–4.61)	0.35
M-classification	1	0.96 (0.22–4.19)	0.95
HER2	Positive	< 0.001 (0–infinity)	0.14
Main reason for NAC	Extended LN	1 (reference)
	Large type 3	1.22 (0.32–4.70)	0.76
	Type 4	1.49 (0.48–4.60)	0.48
	Others	0.62 (0.13–3.02)	0.58
NAC regimen	SP or SOX	1.85 (0.24–14.2)	0.55
Adjuvant treatment	Yes	0.43 (0.05–3.39)	0.42
Participant of clinical trials	Yes	0.79 (0.29–2.14)	0.65

NAC: Neoadjuvant chemotherapy; LN: Lymph node; SP: S-1 + cisplatin; SOX: S-1 + oxaliplatin; DCS: Docetaxel + cisplatin + S-1; HR: Hazard ratio; CI: Confidence interval; ECOG PS: Eastern cooperative oncology group performance status.