Helicobacter pylori virulence genes

Table 2 Overview of studies on homB prevalence and clinical significance in adults and children

Country	Study population	Number of patients	homB prevalence	Clinical relevance of homB	Association with other virulence genes
Western countries[43]	Adults	234	53.8	Significant, PUD	vacA s1, cagA+
East Asian countries[43]	Adults	138	86.8	NS	NS
Western countries[46]	Adults	300	56.0	NA	NA
East Asian countries[46]	Adults	138	86.6	NA	NA
Burkina Faso[46]	Adults	11	90.9	NA	NA
Colombia, United States[47]	Adults	286	61.2	Significant, GC	cagA+
Iran[45]	Adults	138	43.5	Significant, GC	cagA+
Iraq[48]	NA	70	29.9	NS	NS
Turkey[48]	NA	64	33.9	NS	NS
South Korea[44]	Children and adults	260	69.2	NS	vacA
Portugal[49]	Children	45	58.4	Significant, PUD	NA
	Adults	90	57.7	NS	NA
Portugal[42]	Children	84	57.3	Significant, PUD	cagA+, vacA s1, babA2+, hopQI, oipA “on”
	Adults	106	56.8	Significant only in ≤ 40 yr of age, PUD
Portugal[22]	Children	117	53.5	Significant, PUD	jhp0562
Slovenia[50]	Children	285	40.7	NS	NS

NS: Non-significant; NA: Not available; PUD: Peptic ulcer disease; NUD: Non-ulcer dyspepsia; GC: Gastric cancer.