Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

Table 3 Alternative antibiotic Helicobacter pylori eradication therapy using quadruple or levofloxacin-based regimens and associated costs

Regimen	Drug	Dose	Costs(EUR) per dose	Costs (EUR) for 7 d	Costs (EUR) for 14 d
Bismuth quadruple regimen	Tetracycline	500 mg (four times daily)	0.6	12	16.8
	Metronidazole	500 mg (three times daily)	0.6	18.6	26.2
	Pantoprazole (Proton-pump inhibitor)	Standard dose (twice daily)	0.1	2.2	3.0
	Bismuth Subsalicylate	Standard dose (three times daily)	0.3	10.0	14.0
In total			1.6	42.8	60.0
Levofloxacin-based regimen	Levofloxacin	500 mg (once daily)	2.7	27.0	38.0
	Amoxicillin	1 g (twice daily)	1.4	28.8	40.4
	Pantoprazole (Proton-pump inhibitor)	Standard dose (twice daily)	0.1	2.2	3.1
In total			4.2	58.0	81.5
Concomitant regimen	Clarithromycin	500 mg (twice daily)	1.1	22.0	30.8
	Amoxicillin	1 g (twice daily)	1.4	28.8	40.4
	Metronidazole	500 mg (three times daily)	0.6	2.2	3.0
	Pantoprazole (Proton-pump inhibitor)	Standard dose (twice daily)	0.1	18.6	26.0
In total			3.2	72.0	100.0