Treatment of hepatocellular carcinoma in patients with portal vein tumor thrombosis: Beyond the known frontiers

Table 3 Selected studies concerning the outcome of resective surgery in patients with hepatocellular carcinoma and different portal vein tumor thrombosis grades

First author, year	Patients (patients)	PVTT Class (Vp)	Mortality	5-yr survival rate	Median survival time (mo)
Yamaoka, 1992	29	3-4	11%	11.6% (3-yr)	NA
Ikai, 1998	26	3 4	NA	11% 4%	NA
Ohkubo, 2000	47	2-3-4	0%	23.9%	14 mo
Wu, 2000	97 15	1-2-3 4	3.1% 0%	28.5% 26.4%	NA NA
Poon, 2003	20	3-4, Vv2	5.7%	13.3%	6.0 mo
Ikai et al, 2004 (21,711 patients treated from 1989 to 1999)	17,867 1609 672 679	0 1 2 3-4	NA	56.5% 34.4% 27.0% 17.3%	NA
Pawlik, 2005	102	3, Vv 2-3	5.9%	10%	11 mo
Ikai, 2006	78	3-4	3.8%	10.9%	8.9 mo
Chen, 2007	286 152	1-3 4	NA 2.6%	18.1% 0%	10.1 mo
Le Treut, 2006	26	3-4, Vv2-3	11.5%	13%	9.0 mo
Zhou, 2006	381	2-3-4	NA	12%	NA
Shi, 2011	144 189 86 22	1 2 3 4	NA	26.7% (3-yr) 16.9% (3-yr) 3.7% (3-yr) 0% (3-yr)	NA
Inoue et al. 2009	20	4	0%	39.0%	NA
Ban, 2009	45	3 4	0% 0%	41.8% 20.9	20.0 mo
Kondo, 2009	5	4	0%	0%	8.0 mo
Ikai et al 2010 (25,066 patients treated from 1994 to 2005)	20,195 1978 820 1,021	0 1 2 3-4	NA	59.0% 39.1% 23.3% 18.3%	NA
Shi, 2010	169 78	3 4	0.6% 0%	17.7% (3-yr) 3.6% (3-yr)	15.0 mo 10.0 mo
Wang, 2013	25	Vv3	0%	13.5%	NA
Chok, 2013	88	1-2-3-4	3.3%	11.2-14.3%	NA
Pesi, 2015	15 5 21 8 3	1 2 3 Vv2 Vv3	NA	53.3% 30.1% 20.0% NA NA	NA
Xu, 2015	16 40	A B	100% NA	0% 5.2%	NA
Kokudo, 2016	1772 1475 1942 1285	1 2 3 4	NA	NA	2.67 yr 1.51 yr 0.78 yr 0.50 yr
Kudo, 2016	1908 714 852	1 2 3-4	NA	48.2% 29.2% 25.05	NA

NA: Not available; PVTT: Portal vein tumor thrombosis.