NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production

Figure 6 Schematic model of the role of NKX6. 3 in gastric mucosal atrophy. In gastric mucosal cells, NKX6.3 prevents gastric mucosal atrophy by regulating amyloid β (Aβ) peptide accumulation and oligomerization through inhibiting the γ-secretase complex formation and the expression of apolipoprotein E (ApoE), and β-secretase 1. In addition, NKX6.3 suppresses gastric mucosal inflammation by modulating ApoE-induced nuclear factor kappa B activity and expression of cytokines. Aβ: Amyloid β; ApoE: Apolipoprotein E; Bace1: β-secretase 1; NF-κB: Nuclear factor kappa B.