Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota

Figure 2 Caloric restriction and Lingguizhugan decoction treatment reduces body weight and blood glucose levels in normal diet-fed C57BL/6J mice. Eight-week-old male C57BL/6J mice received control treatment (pink) or caloric restriction and Lingguizhugan decoction (CR + LZD) (green) for 16 wk; n = 10 per group. A: Body weight was monitored biweekly during the study period, and each point and error represents the mean ± standard error; B: Accumulated food intake during experimental period; C: Fasting blood glucose levels were measured on weeks 0 and 16; D: Plasma total cholesterol levels; E: Plasma total triglyceride levels; F-H: Plasma alanine transaminase (ALT) and aspartate transaminase (AST) activity, and AST/ALT ratio; I: Plasma blood urea nitrogen levels. Data were evaluated for statistical significance by student’s t-test and are represented as follows: ^aP < 0.05 CR + LZD treatment vs Control treatment. CR: Caloric restriction; LZD: Lingguizhugan decoction; AST: Aspartate transaminase; ALT: Alanine transaminase; BUN: Blood urea nitrogen.