Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis

Table 2 Association between clinicopathological characteristics and growth patterns

Characteristic		Group A	Group B	P-value
Sex	Male	9	10	0.6999
	Female	6	4
Age	Mean ± SD	67.5 ± 9.6	62.3 ± 13.6	0.2774
	Median	67	60.5
	Range	50-82	43-82
Serum CEA level	Mean ± SD	15.5 ± 25.2	46.9 ± 148.7	0.3823
(μg/L)	Median	3.7	5.65
	Range	0.9-88.0	1.1-563.2
Localization	Cecum	3	3	0.6621
	Ascending	2	0
	Transverse	1	1
	Descending	1	0
	Sigmoid	2	3
	Rectum	6	7
Size (cm)	Mean ± SD	4.2 ± 1.3	4.3 ± 2.4	0.5814
	Median	4.6	4
	Range	2.0-6.0	2.0-11.0
Configuration	Exophytic	7	7	0.2643
	Endophytic	8	5
	N/A	0	2
Histologic grade	G1	5	7	0.3060
	G2	8	7
	G3	2	0
Tumor depth	T1	0	0	0.6999
	T2	0	0
	T3	9	10
	T4	6	4
Lymph node metastasis	Positive	9	10	0.6999
	Negative	6	4
Tumor budding score (TBS)	High	1	7	0.0275
	Intermediate	4	3
	Low	10	4
	Negative	0	0
Tumor deposits	Positive	3	4	0.6817
	Negative	12	10
Lymphovascular invasion	Positive	11	12	0.6513
	Negative	4	2
Perineural invasion	Positive	10	12	0.3898
	Negative	5	2
Peri-tumoral inflammatory cell band	Negative	5	4	0.5974
	Low grade	8	6
	High grade	2	4
Crohn’s disease-like response	Positive	7	1	0.0352
	Negative	8	13
Histologic growth pattern	EGP	9	2	0.0209
	IGP	6	12

SD: Standard deviation; CEA: Carcinoembryonic antigen; NA: Not available; EGP: Expanding growth pattern; IGP: Infiltrating growth pattern.