Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

Table 3 Current literature summary on the application of aptamers in targeted therapy for liver cancer

First author	Year	Aptamer	Target	System for therapy	Function
Hu et al[66]	2018	TLS11a	H22 cells	TLS11a/CD3	Immunity therapy
Xiao et al[67]	2017	EpDT3	EpCAM-positive cells HepG2	EpDT3-PEG-Ad5-PTEN (EPAP)	Gene therapy
Babaei et al[69]	2017	EpCAM-Apt	EpCAM-positive cells HepG2	EpCAM-PEG-Au@Si-5-FU NPs	Chemotherapy
Lan et al[70]	2019	TLS11a	HepG2 cells	Apt-BMSF@Pt	Phototherapy
Liu et al[72]	2016	ST21	SK-Hep-1 cells	FasudilST21-H3R5-PEG miR195	Chemotherapy and gene therapy
Cheng et al[73]	2019	TLS1c	MEAR cells	BioTL Cab/lipo	Chemotherapy