Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

Table 2 Current literature summary of aptamers for in vivo imaging of liver cancer

First author	Year	Aptamer	Type of tumor	Probe for detection	Method for detection
Yan et al[59]	2018	CD105-Apt	Tiny HCC	Conjugated CD105-Apt to paramagnetic and fluorophore on the G5 dendrimer	MRI
Zhong et al[60]	2019	mEND	HCC	mEND-Fe O @CMCS	MRI
Zhao et al[61]	2018	AP613-1	HCC expressing GPC3	Apt-USPIO	MRI
Babaei et al[69]	2017	EpCAM-Apt	HCC	EpCAM-PEG-Au@Si-5-FU NPs	CT

Apt: Aptamer; HCC: Hepatocellular carcinoma; MRI: Magnetic resonance imaging; CT: Computed tomography; USPIO: Ultrasmall superparamagnetic iron oxide.