Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study

Table 3 Factors associated with the values of liver stiffness measured by magnetic resonance elastography and two-dimensional shear wave elastography in univariate and multivariate linear regression analyses

Parameters	Factors associated with liver stiffness values by MRE				Factors associated with liver stiffness values by 2D-SWE
	Univariate	P value	Multivariate	P value	Univariate	P value	Multivariate	P value
Sex, male/female	-0.054 (-0.508, 0.401)	0.815			0.685 (-0.840, 2.210)	0.372
Age, yr	0.019 (-0.006, 0.044)	0.132			0.067 (-0.017, 0.151)	0.117
BMI, kg/m2	-0.048 (-0.114, 0.018)	0.149			-0.251 (-0.469, -0.034)	0.024	-0.186 (-0.366, -0.007)	0.042
AST, U/L	0.007 (-0.003, 0.017)	0.157			0.032 (-0.001, 0.065)	0.054
ALT, U/L	0.002 (-0.009, 0.013)	0.674			0.000 (-0.037, 0.037)	0.995
PLT counts, × 103/mm3	-0.007 (-0.012, -0.001)	0.014	0.001 (-0.002, 0.005)	0.530	-0.027 (-0.045, -0.009)	0.004	-0.012 (-0.029, 0.004)	0.136
PT, INR	1.312 (-1.595, 4.220)	0.370			8.658 (-0.971, 18.288)	0.077
Total bilirubin, mg/dL	0.331 (-0.140, 0.802)	0.165			0.098 (-1.517, 1.713)	0.904
Albumin, g/dL	-0.540 (-1.510, 0.429)	0.270			-3.152 (-6.359, 0.055)	0.054
γ-GT, U/L	0.004 (-0.003, 0.011)	0.302			0.012 (-0.012, 0.036)	0.327
HBeAg status, +/-	0.166 (-0.282, 0.615)	0.461			1.052 (-0.445, 2.549)	0.165
HBV-DNA, log10 IU/mL	-0.051 (-0.189, 0.086)	0.456			-0.076 (-0.541, 0.389)	0.745
Inflammatory grade	0.363 (0.153, 0.573)	0.001	0.105 (-0.031, 0.241)	0.129	0.903 (0.163, 1.644)	0.018	0.220 (-0.411, 0.852)	0.487
Fibrosis stage	0.626 (0.520, 0.732)	< 0.001	0.609 (0.487, 0.731)	< 0.001	1.616 (1.116, 2.116)	< 0.001	1.276 (0.690, 1.863)	< 0.001

MRE: Magnetic resonance elastography; 2D-SWE: Two-dimensional shear wave elastography; ALT: Alanine transaminase; AST: Aspartate transaminase; BMI: Body mass index; INR: International normalized ratio; PLT: Platelet; PT: Prothrombin time; γ-GT: Gamma-GT.