Modified FOLFIRINOX for resected pancreatic cancer: Opportunities and challenges

Table 1 Comparison of six phase III clinical trials of gemcitabine alone in patients with resected pancreatic cancer

Trial	PRODIGE-24[1]	CONKO-001[9]	ESPAC-3[10]	JASPAC 01[13]	ESPAC-4[11]	CONKO-005[12]
Variable
No. of patients	246	179	537	190	366	217
Tumor grade, n (%)
Well differentiated	79 (32.1)	10 (5.6)	66 (12.3)	NA	30 (8.2)	9 (4.1)
Moderately differentiated	125 (50.8)	103 (57.5)	336 (62.6)	NA	192 (52.5)	128 (59)
Poorly differentiated/undifferentiated	29 (11.8)	63 (35.2)	127 (23.6)	NA	142 (38.8)	74 (34.1)
Disease free survival - mo
Median	12.8	13.4	14.3	11.3	13.1	11.4
95%CI	11.7-15.2	11.4-15.3	13.5-15.6	9.7-13.6	11.6-15.3	9.2-13.6
Overall survival - mo
Median	35.0	22.1	23.6	25.5	25.5	26.5
95%CI	28.7-43.9	18.4-25.8	21.4-26.4	22.5-29.6	22.7-27.9	22.4-30.6

NA: Not available; CI: Confidence interval.