Autoimmune hepatitis treatment in the elderly: A systematic review

Table 4 Outcome definitions

Author (year)	Remission	Treatment failure	Relapse
Schramm et al[6], 2001	IAIHG revised criteria (1999)	-	IAIHG revised criteria (1999)
Granito et al[21], 2005	IAIHG revised criteria (1999)	-	IAIHG revised criteria (1999)
Al-Chalabi et al[23], 2006	IAIHG revised criteria (1999)	IAIHG original criteria (1993)	IAIHG revised criteria (1999)
	PR: IAIHG original criteria (1993)
Czaja et al[9], 2006	Symptoms: Absent	Worsening of clinical, laboratory and/or histological alterations despite compliance to therapy	Symptom recurrence and increased serum AST level (> three-fold the ULN) after drug withdrawal
	AST level: Normal or near normal (< two-fold the UNL)
	Histology: Minimal/no inflammation
	SR:
	Symptoms: Absent
	Serum AST levels: Normal or below the relapse threshold
	after drug withdrawal
Zhang et al[22], 2012	Symptoms: Absent	Worsening of clinical, laboratory and/or histological alterations despite compliance to therapy	Symptom recurrence and increased serum AST level (> three-fold the ULN) after drug withdrawal
	AST levels: Normal or near normal (< two-fold the UNL)
	Histology: Minimal or no inflammation.
	SR:
	Symptoms: Absent
	AST levels: Normal or below the relapse threshold after drug withdrawal
Zachou et al[20], 2016	CR:	Persistently elevated AST and ALT (> three-fold the UNL) and/or increased IgG despite intensive immunosuppression and compliance to therapy	Rise in AST and ALT levels (> three-fold the UNL) and/or increased IgG (> 2000 mg/dL) during therapy with or without symptom recurrence after initial CR
	Symptoms: Improved
	AST, ALT, IgG levels: normal
	Histology: Minimal/no inflammation
	PR:
	ALT or AST levels: Decreased (< two-fold ULN) without achieving complete normalization and inability to withdraw or taper prednisolone
Morii et al[24], 2017	Normal serum ALT and IgG levels	-	Re-exacerbation not explicitly defined

IAIHG: International Autoimmune Hepatitis Group; ALT: Alanine transaminase; AST: Aspartate transaminases; ULN: Upper limit of normal; IgG: Immunoglobulin G; CR: Complete remission; PR: Partial remission; SR: Sustained remission.