Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease

Table 1 Baseline characteristics of the study population

HCs (n = 500)		ITB (n = 133)	CD (n = 128)	P-value
Gender (Female/male)	237/263	37/96	42/86	0.42
Age of diagnosis (yr)	38.5 ± 12.8	41.0 ± 17.2	37.4 ± 16.1	0.06
Smokers, n (%)	103/500 (20.6)	32/133 (24.1)	22/128 (17.2)	0.22
Drinkers, n (%)	56/500 (11.2)	17/133 (12.8)	15/128 (11.7)	0.85
WBC (109/L)		7.08 ± 4.0	7.95 ± 3.5	0.10
Hb, g/L		113.56 ± 23.1	109.83 ± 25.8	0.28
ESR, mm/h		37.43 ± 25.6	34.60 ± 25.6	0.50
PPD (positive), n (%)		34/49 (69.4)	11/35 (31.4)	0.06
T-SPOT (positive), n (%)		20/26 (76.9)	3/27 (11.1)	0.002
TB not examined		58	62
Abnormal lung imaging findings, n (%)		50/133 (37.6)	3/128 (2.3)	< 0.0001
Remission rate: n (%)
5-ASA			77/128 (60.2)
Glucocorticoids			31/128 (24.2)
Immunosuppressors			5/128 (3.9)
Anti-TNF			8/128 (6.2)
Non-remission			7/128 (5.5)
Disease related surgery, n (%)		21/133 (15.8)	29/128 (22.7)	0.21
Location of ITB, n (%)
Small intestine		11/133 (8.3)
Ileocecus		77/133 (57.9)
Colon		37/133 (27.8)
Data not available		8/133 (6.0)
Location of CD, n (%)
L1 ± L4			60/128 (46.9)
L2 ± L4			36/128 (28.1)
L3 ± L4			29/128 (22.7)
L4			3/128 (2.3)
Behavior of CD, n (%)
B1—Inflammatory			81/128 (63.3)
B2—Stricturing			37/128 (28.9)
B3—Penetrating			10/128 (7.8)
p—Perianal			35/128 (27.3)

Smokers: Subjects who had smoked more than one cigarette per day for at least one year; Drinkers: Subjects who had drunk alcohol per week for more than six months; WBC: White blood cells; Hb: Haemoglobin; ESR: Erythrocyte sedimentation rate; T-SPOT: T cell spot test; PPD: Purified protein derivative; 5-ASA: 5-Aminosalicylic acid; CD: Crohn’s disease; L1: Terminal ileum (phenotype defined by the Montreal Classification System); L2, Colonic; L3, Ileocolonic; L4: Upper gastrointestinal tract; TNF: tumour necrosis factor. Bold indicates the statistical significance (P < 0.05).