Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus

Figure 3 Bi-cluster analysis of the differentially expressed genes in the trans-regulatory networks existing in both the GSE1420 and GSE26886 datasets. Each row represents one of the differentially expressed genes (DEGs) in the trans-regulatory networks, and each column represents a tissue sample from the two datasets (GSE1420 and GSE26886). The column “normal esophagus (NE)” represents normal esophagus tissue, the column “Barrett's esophagus (BE)” represents Barrett's esophagus tissue, and the column “esophageal adenocarcinoma (EAC)” represents tissue from esophageal adenocarcinoma. The heat map was constructed using each DEG expression value in every tissue sample. A: The heat map for the comparison group of EAC vs. NE in the GSE1420 dataset; B: The heat map for the comparison group of EAC vs NE in the GSE26886 dataset; C: The heat map for the comparison group of BE vs NE in the GSE1420 dataset; D: The heat map for the comparison group of BE vs NE in the GSE26886 dataset.