Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i2.269

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 2

This Article

(428)

(402)

(0)

(19)

(7899)

(41)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Observational Study

World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269

Table 2 Correlations between brain-derived neurotrophic factor levels and clinical and experimental parameters in patients with diarrhea-predominant irritable bowel syndrome

	BDNF expression
Clinical characteristic
Severity of abdominal pain	0.565 (0.001)^a
IBS-SSS	0.393 (0.029)^b
Visceral sensitivity
First sensation threshold	-0.562 (0.001)^a
Defecating sensation threshold	-0.015 (0.938)
Maximum tolerable threshold	-0.290 (0.113)
RAIR threshold	-0.508 (0.004)^a
Mucosal nerve fiber density	-0.058 (0.756)

Spearman’s correlation coefficients are presented with P-values in parentheses.

^aP with significance after Bonferroni correction (adjusted P < 0.0071).

^bP without significance after Bonferroni correction (adjusted P < 0.0071). BDNF: Brain-derived neurotrophic factor; IBS-SSS: IBS Symptom Severity Scale; RAIR: Rectoanal inhibition reflex.

Full Size Table

Citation: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.269

Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281 [PMID: 30670915 DOI: 10.3748/wjg.v25.i2.269]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.