Current status, problems, and perspectives of non-alcoholic fatty liver disease research

Table 1 Biomarkers predicting ≥ F3 fibrosis in Japanese non-alcoholic fatty liver disease patients

Biomarker	Fibrosis stage	Cut-off value	AUC	Ref.
Platelet count	F4	15.3 × 104/μL	0.92	[58]
	F4	16 × 104/μL	0.98	[59]
Hyaluronic acid	≥ F3	42 ng/mL	0.97	[59]
Type 4 collagen 7S	≥ F3	6.0 ng/mL	0.88	[60]
Mac2-binding protein	≥ F3	2.24 μg/mL	0.78	[61]
WFA+Mac2-binding protein	≥ F3	0.83 COI	0.82	[60]
	≥ F3	1.23 COI	0.83	[62]
Autotaxin	≥ F3	1.19 mg/L	0.75	[63]
	F4	1.20 mg/L	0.87

AUC: Area under the receiver operating characteristic curve.