High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

doi:10.3748/wjg.v25.i19.2383

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastroenterol. May 21, 2019; 25(19): 2383-2401
Published online May 21, 2019. doi: 10.3748/wjg.v25.i19.2383

Table 8 Diagnostic accuracy parameters for significant colonic lesion detection based on quantitative faecal immunochemical test for haemoglobin threshold concentration and brand

Brand	Threshold(µg/g faeces)	Author, year	Sensitivity¹	Specificity¹
Significant colonic lesion (100% symptomatic)
OC-Sensor^®	15	Cubiella (DC), 2014[29]	76.2 (72.0-80.0)	74.4 (71.7-76.9)
OC-Sensor^®	15	Cubiella (VC), 2017[31]	89.5 (84.1-93.6)	40.6 (36.4-44.9)
OC-Sensor^®	20	Cubiella (DC), 2014[29]	74.7 (70.5-78.6)	76.1 (73.5-78.6)
OC-Sensor^®	20	Cubiella (VC), 2017[31]	87.8 (82.2-92.2)	42.1 (37.9-46.5)
HM-JACKarc^®	10	Godber, 2016[27]	68.9 (53.2-81.4)	80.2 (76.1-83.7)
HM-JACKarc^®	15	Godber, 2016[27]	66.7 (50.9-79.6)	83.1 (79.2-86.5)
HM-JACKarc^®	20	Godber, 2016[27]	64.4 (48.7-77.7)	85.7 (81.9-88.7)
HM-JACKarc^®	25	Godber, 2016[27]	64.4 (48.7-77.7)	87.5 (83.9-90.3)
HM-JACKarc^®	30	Godber, 2016[27]	64.4 (48.7-77.7)	88.6 (85.2-91.4)
HM-JACKarc^®	35	Godber, 2016[27]	64.4 (48.7-77.7)	89.2 (85.9-92.0)
HM-JACKarc^®	40	Godber, 2016[27]	64.4 (48.7-77.7)	90.0 (86.7-92.5)

¹Values are expressed as percentages and their 95% confidence interval. DC: Derivation cohort; VC: Validation cohort.

Citation: Pin Vieito N, Zarraquiños S, Cubiella J. High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis. World J Gastroenterol 2019; 25(19): 2383-2401
URL: https://www.wjgnet.com/1007-9327/full/v25/i19/2383.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i19.2383