Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection

Table 4 Univariate and multivariate analyses of risk factors associated with post-admission progression to acute-on-chronic liver failure

Variable	Univariate analysis				Multivariate analysis
	Β	OR	95%CI	P-value	β	OR	95%CI	P-value
MELD	0.161	1.175	1.049-1.315	0.005	0.184	1.202	1.033-1.398	0.017
HBV DNA	0.380	1.463	1.018-2.101	0.040
AST	0.001	1.001	1.000-1.002	0.013	0.001	1.001	1.000-1.002	0.021
PTA	-0.252	0.777	0.704-0.858	0.000	-0.257	0.758	0.672-855	0.000
LC	1.128	3.091	1.280-7.465	0.012	2.125	8.369	2.389-29.322	0.001

ACLF: Acute-on-chronic liver failure; CI: Confidence interval; OR: Odds ratio; AST: Aspartate aminotransferase; LC: Liver cirrhosis; MELD: Model for end-stage liver disease; PTA: Prothrombin activity.