Recent advances in gastric cancer early diagnosis

Table 2 Various aberrantly expressed circular RNAs with the potential to serve as diagnostic and prognostic biomarkers for gastric cancer

circRNA name	Biological function	Type of biomarker	Origin of specimen	Sensitivity/specificity	Study
hsa_circ_002059	Downregulated in GC; correlated with TNM stage and metastasis	Diagnostic	Tissues; plasma	81%/62%	Li et al[94]
hsa_circ_0000096	Downregulated in GC; affects GC cell growth and migration	Diagnostic	Tissues	N/S	Li et al[99]
hsa_circ_0058246	Upregulated in GC; associated with poor clinical outcomes	Prognostic	Tissues	N/S	Fang et al[100]
hsa_circ_0000745	Downregulated in GC; correlated with tumor differentiation and tumor nodal metastasis	Prognostic	Tissues	85.5%/45%	Huang et al[101]
hsa_circ_00000181	Downregulated in GC; associated with TNM stage and metastasis	Prognostic	Plasma	99%/85.2%	Zhao et al[102]
hsa_circ_0047905, has-circRNA7690-15, hsa_circ_0138960	Substantially upregulated in GC; act as tumor promoters in the pathogenesis of GC	Diagnostic	Tissues	N/S	Lai et al[103]
hsa_circ_0014717	Downregulated in GC; stably expressed in gastric juice; associated with TNM stage and metastasis	Prognostic	Tissues	59.38%/81.25%	Shao et al[104]
hsa_circ_0001895	Downregulated in both GC tissue and gastric precancerous lesions	Diagnostic	Tissues	67.8%/85.7%	Shao et al[105]
has_circ_0000520	Downregulated in GC; associated with TNM stage and in GC plasma linked with CEA expression	Diagnostic	Tissues; plasma	53.57%/85.71% (tissue) 82.35%/84.44% (plasma)	Sun et al[106]
hsa_circ_0000190	Downregulated in GC; associated with TNM stage and metastasis	Diagnostic	Tissues; plasma	71.2%/75%	Chen et al[107]
hsa_circ_0001017 hsa_circ_0061276	Downregulated in GC; associated with shorter overall survival	Prognostic	Tissues; plasma	95.5%/95.7%	Li et al[108]

GC: Gastric cancer; CEA: Carcinoembryonic antigen; circRNA: Circular RNA; N/S: Not specified.