Repurposing drugs to target nonalcoholic steatohepatitis

Table 1 Non-alcoholic fatty liver disease-Kyoto Encyclopedia of Genes and Genomes pathway (hsa04932)

Gene symbol; description
IL6; interleukin 6
IL6R; interleukin 6 receptor
SOCS3; suppressor of cytokine signaling 3
TNF; tumor necrosis factor
TNFRSF1A; TNF receptor superfamily member 1A
NFKB1; nuclear factor kappa B subunit 1
RELA; RELA proto-oncogene, NF-kB subunit
INS; insulin
INSR; insulin receptor
IRS1; insulin receptor substrate 1
IRS2; insulin receptor substrate 2
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
AKT1; AKT serine/threonine kinase 1
AKT2; AKT serine/threonine kinase 2
AKT3; AKT serine/threonine kinase 3
GSK3A; glycogen synthase kinase 3 alpha
GSK3B; glycogen synthase kinase 3 beta
NR1H3; nuclear receptor subfamily 1 group H member 3
RXRA; retinoid X receptor alpha
SREBF1; sterol regulatory element binding transcription factor 1
MLX; MLX, MAX dimerization protein
MLXIP; MLX interacting protein
MLXIPL; MLX interacting protein like
PKLR; pyruvate kinase L/R
LEP; leptin
LEPR; leptin receptor
ADIPOQ; adiponectin, C1Q and collagen domain containing
ADIPOR1; adiponectin receptor 1
ADIPOR2; adiponectin receptor 2
PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
PPARA; peroxisome proliferator activated receptor alpha
CDC42; cell division cycle 42
RAC1; Rac family small GTPase 1
MAP3K11; mitogen-activated protein kinase kinase kinase 11
MAPK8; mitogen-activated protein kinase 8
MAPK10; mitogen-activated protein kinase 10
MAPK9; mitogen-activated protein kinase 9
ITCH; itchy E3 ubiquitin protein ligase
ERN1; endoplasmic reticulum to nucleus signaling 1
TRAF2; TNF receptor associated factor 2
MAP3K5; mitogen-activated protein kinase kinase kinase 5
JUN; Jun proto-oncogene, AP-1 transcription factor subunit
IL1A; interleukin 1 alpha
IL1B; interleukin 1 beta
IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
XBP1; X-box binding protein 1
CEBPA; CCAAT enhancer binding protein alpha
CYP2E1; cytochrome P450 family 2 subfamily E member 1
FASLG; Fas ligand
CXCL8; C-X-C motif chemokine ligand 8
TGFB1; transforming growth factor beta 1
EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
ATF4; activating transcription factor 4
DDIT3; DNA damage inducible transcript 3
BCL2L11; BCL2 like 11
BAX; BCL2 associated X, apoptosis regulator
FAS; Fas cell surface death receptor
CASP8; caspase 8
BID; BH3 interacting domain death agonist
CYCS; cytochrome c, somatic
CASP3; caspase 3
CASP7; caspase 7
NDUFV1-3; NADH:ubiquinone oxidoreductase core subunit V1 –V3
NDUFA1-3; NADH:ubiquinone oxidoreductase subunit A1-3
NDUFA4; NDUFA4, mitochondrial complex associated
NDUFA4L2; NDUFA4, mitochondrial complex associated like 2
NDUFA5-13; NADH:ubiquinone oxidoreductase subunit A5-A13
NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1
NDUFB1-11; NADH:ubiquinone oxidoreductase subunit B1-B11
NDUFS1-S8; NADH:ubiquinone oxidoreductase core subunit S1 –S8
NDUFC1; NADH:ubiquinone oxidoreductase subunit C1
NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
NDUFC2-KCTD14; NDUFC2-KCTD14 readthrough
SDHA; succinate dehydrogenase complex flavoprotein subunit A
SDHB; succinate dehydrogenase complex iron sulfur subunit B
SDHC; succinate dehydrogenase complex subunit C
SDHD; succinate dehydrogenase complex subunit D
UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
CYTB; cytochrome b
CYC1; cytochrome c1
UQCRC1; ubiquinol-cytochrome c reductase core protein 1
UQCRC2; ubiquinol-cytochrome c reductase core protein 2
UQCRH; ubiquinol-cytochrome c reductase hinge protein
UQCRHL; ubiquinol-cytochrome c reductase hinge protein like
UQCRB; ubiquinol-cytochrome c reductase binding protein
UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII
UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X
UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI
COX3; cytochrome c oxidase III
COX1; cytochrome c oxidase subunit I
COX2; cytochrome c oxidase subunit II
COX4I2; cytochrome c oxidase subunit 4I2
COX4I1; cytochrome c oxidase subunit 4I1
COX5A; cytochrome c oxidase subunit 5A
COX5B; cytochrome c oxidase subunit 5B
COX6A1; cytochrome c oxidase subunit 6A1
COX6A2; cytochrome c oxidase subunit 6A2
COX6B1; cytochrome c oxidase subunit 6B1
COX6B2; cytochrome c oxidase subunit 6B2
COX6C; cytochrome c oxidase subunit 6C
COX7A1; cytochrome c oxidase subunit 7A1
COX7A2; cytochrome c oxidase subunit 7A2
COX7A2L; cytochrome c oxidase subunit 7A2 like
COX7B; cytochrome c oxidase subunit 7B
COX7B2; cytochrome c oxidase subunit 7B2
COX7C; cytochrome c oxidase subunit 7C
COX8C; cytochrome c oxidase subunit 8C
COX8A; cytochrome c oxidase subunit 8A

https://http://www.genome.jp/kegg-bin/show_pathway? hsa04932.