Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients

Table 3 Serology, dietary adherence (3-d recall) and gluten immunogenic peptide excretion tests in samples from patients with celiac disease responding to the gluten-free diet (asymptomatic cases)

Patient No.	Serology		First set of determinations				Second set of determinations
	IgAtTG AU/mL	IgADGPAU/mL	Dietary report	GIP in stool ELISA μg/g	GIP in stool PoCT	GIP in urine PoCT	Dietary report	GIP in stool ELISA μg/g	GIP in stool PoCT	GIP in urine PoCT
1	12	10	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
2	11	36	NA	0.19	ND	-ve	NA	< 0.16	ND	-ve
3	14	13	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
4	5	7	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
5	17	22	Strict	< 0.16	-ve	-ve	Strict	< 0.16	+ve	-ve
6	32	58	NA	< 0.16	-ve	-ve	NA	ND	ND	ND
7	16	41	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
8	6	11	NA	< 0.16	-ve	+ve	NA	< 0.16	-ve	-ve
9	33	18	NA	< 0.16	-ve	-ve	NA	< 0.16	-ve	-ve
10	2	2	NA	0.38	+ve	-ve	NA	0.75	+ve	-ve
11	40	23	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
12	12	6	NA	< 0.16	-ve	-ve	NA	< 0.16	-ve	-ve
13	8	20	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
14	8	25	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
15	9	ND	NA	< 0.16	-ve	-ve	NA	< 0.16	-ve	-ve
16	10	25	NA	< 0.16	-ve	-ve	NA	0.66	+ve	+ve
17	15	ND	Strict	0.26	-ve	-ve	Strict	< 0.16	-ve	-ve
18	32	16	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
19	ND	ND	NA	< 0.16	-ve	-ve	NA	< 0.16	-ve	-ve
20	11	21	Traces	< 0.16	-ve	-ve	NA	ND	ND	ND
21	6	13	Traces	< 0.16	-ve	-ve	NA	< 0.16	-ve	-ve
22	100	78	ND	0.66	-ve	+ve	ND	ND	ND	ND
23	8	8	Strict	0.26	-ve	-ve	Strict	0.75	-ve	-ve
24	17	22	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve
25	6	6	Strict	< 0.16	-ve	-ve	Strict	< 0.16	-ve	-ve

Dietary assessments were categorized as “strict” (patients with no transgression detected) or no adherence (by sources: transgression by foods with potential gluten sources or by traces: patients with potential intake of gluten traces). Gluten immunogenic peptidesin stool by enzyme-linked immunosorbent assay<0.156: no gluten excretion detected. NA: No adherence;ND: Not determined and excluded from analysis; -ve: Negative result; +ve: Positive result; DGP: Deamidated gliadin peptide; GIP: Gluten immunogenic peptides; ELISA: Enzyme-linked immunosorbent assay; PoCT: Point-of-care test.