Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer

Table 2 Multivariate analyses of prognostic factors associated with progression-free survival using Cox-regression

	P value	Hazard ratio	CI lower	CI upper
N-category	0.02	0.569	0.349	0.927
LVI	0.004	2.559	1.347	4.862
PNI	0.538	0.837	0.476	1.473
CRM	0.004	2.931	1.398	6.143
Bormann type	0.3	0.731	0.402	1.327
SLAMF7	0.003	0.206	0.072	0.589
CKS2	0.018	0.484	0.266	0.883
TREM1	0.017	0.471	0.254	0.875

CI: Confidence interval; CKS-2: Cyclin-dependent kinases regulatory subunit 2; CRM: Circumferential resection margin; LVI: Lymphovascular invasion; PNI: Perineural invasion; SLAMF7: Signaling lymphocytic activation molecule family, member 7; TREM1: Triggering receptor expressed on myeloid cells 1.