Basic Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Mar 21, 2019; 25(11): 1341-1354
Published online Mar 21, 2019. doi: 10.3748/wjg.v25.i11.1341
Table 1 Association between differential regulation of 19-gene-based risk classifier genes and clinicopathological factors in 60 patients with stage IV colorectal cancer
Variables (No. of patients)Percentage of tumors with a log22-ΔΔCT value > 1 compared with matched normal tissue (P value)
GADD45B1S1PR3CDKN2BEGR2CTGFSERPINE1RGS16RHOUTIMP1PHLDA1IL36RNSLAMF7E2F7DTLCFBCDK1CXCL1CXCL3CKS2TREM1
Mean ± SEM of 2ΔΔCT0.78 ± 0.741.45 ± 4.231.64 ± 6.033.24 ± 10.881.23 ± 1.668.19 ± 22.4910.39 ± 35.491.01 ± 1.592.90 ± 2.795.49 ± 14.954.40 ± 15.221.17 ± 5.109.84 ± 34.232.46 ± 4.683.29 ± 5.622.94 ± 6.5122.76 ± 75.7930.55 ± 76.032.65 ± 4.1414.14 ± 71.65
Sex25.9/24.225.9/27.322.2/15.233.3/39.437.0/36.474.1/81.881.5/69.733.3/24.274.1/75.863.0/66.733.3/42.43.7/18.285.2/84.844.4/60.670.4/69.751.9/60.692.6/78.896.3/84.855.6/75.829.6/42.4
Female/male (27/33)0.560.570.350.420.580.340.230.310.560.490.330.890.630.160.590.340.130.150.080.23
Age23.2/50.026.8/25.017.9/25.037.5/25.035.7/50.076.8/10075.0/75.028.6/25.073.2/10064.3/75.039.3/25.010.7/25.083.9/10055.4/25.071.4/50.058.9/25.083.9/10089.3/10066.1/75.035.7/50.0
≤ 75 vs > 75 (56/4)0.260.710.570.530.470.370.690.680.310.560.50.40.510.260.350.210.510.650.590.47
Comorbidity20.0/32.031.4/20.020.0/16.042.9/28.037.1/36.074.3/84.080.0/.68.034.3/20.068.6/84.062.9/68.045.7/28.08.6/16.080.0/92.060.0/44.071.4/68.068.6/40.082.9/88.088.6/92.068.6/64.037.1/36.0
No/Yes (35/25)0.220.250.480.180.570.280.220.180.140.450.130.310.180.170.50.030.430.510.460.57
Family history24.0/30.028.0/20.018.0/20.038.0/30.036.0/40.078.0/80.072.0/90.028.0/30.074.0/80.064.0/70.042.0/20.012.0/10.088.0/70.056.0/40.070.0/70.060.0/40.088.0/70.094.0/70.072.0/40.036.0/40.0
No/Yes (50/10)0.480.460.590.460.540.630.220.590.520.510.170.670.160.280.630.210.160.050.060.54
Synchronous Lm33.3/21.433.3/23.822.2/16.733.3/38.133.3/38.172.2/81.083.3/71.444.4/21.477.8/73.866.7/64.344.4/35.722.2/7.172.2/90.555.6/52.483.3/64.372.2/50.0100/78.6100/85.783.3/59.538.9/35.7
No/Yes (18/42)0.250.320.430.480.480.330.260.070.510.550.360.110.080.520.120.090.030.10.060.52
Synchronous Pm28.9/13.326.7/26.717.8/20.037.8/33.335.6/40.077.8/80.077.8/66.731.1/20.077.8/66.766.7/60.040.0/33.313.3/6.786.7/80.057.8/40.071.1/66.762.2/40.088.9/73.391.1/86.766.7/66.740.0/26.7
No/Yes (45/15)0.20.640.560.510.490.580.30.320.30.430.440.430.40.180.490.110.150.470.620.27
AJCC stage0/25.90/27.60/110/37.950/36.250/79.3100/74.150/27.60/77.650/65.550/37.90/12.1100/84.5100/51.7100/69.0100/55.2100/84.5100/89.7100/65.50/37.9
III/IV (2/58)0.560.530.660.40.60.390.560.490.060.580.620.780.720.280.490.320.720.810.440.4
LVI10.0/32.520.0/30.015.0/20.025.0/42.525.0/42.565.0/85.065.0/80.030.0/27.575.0/75.045.0/75.025.0/45.00/17.570.0/92.535.0/62.560.0/75.045.0/62.575.0/90.085.0/92.555.0/72.530.0/40.0
No/Yes (20/40)0.050.310.470.150.150.080.170.530.630.020.110.050.030.040.180.160.130.310.140.32
PNI12.0/34.332.0/22.916.0/20.040.0/34.332.0/40.076.0/80.060.0/85.736.0/22.972.0/77.156.0/71.440.0/37.18.0/14.376.0/91.452.0/54.368.0/71.456.0/57.176.0/91.484.0/94.364.0/68.624.0/45.7
No/Yes (25/35)0.040.310.480.430.360.470.020.20.440.170.520.370.10.530.50.570.10.190.460.07
CRM involvement22.4/36.426.5/27.318.4/18.234.7/45.538.8/27.379.6/72.773.5/81.830.6/18.273.5/81.863.3/72.736.7/45.56.1/36.483.7/90.951.0/63.669.4/72.753.1/72.785.7/81.889.8/90.961.2/90.930.6/63.6
No/Yes (49/11)0.270.610.680.370.360.440.440.340.440.410.420.020.470.340.570.20.520.70.050.04