Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma

doi:10.3748/wjg.v25.i1.42

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2019; 25(1): 42-58
Published online Jan 7, 2019. doi: 10.3748/wjg.v25.i1.42

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Figure 6 Interaction between the PPARα signaling pathway and HCV core protein. HCV core protein can directly and indirectly activate PPARα, and PPARα activation increases liver triglyceride accumulation, leading to hepatic steatosis. See the text for more details. PPARα: Peroxisome proliferator-activated receptor α; ROS: Receptor tyrosine kinase c-ros oncogene 1; RXR: Retinoid X receptor; PPRE: Peroxisome proliferator hormone response elements.

Citation: Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol 2019; 25(1): 42-58
URL: https://www.wjgnet.com/1007-9327/full/v25/i1/42.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i1.42

Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol 2019; 25(1): 42-58 [PMID: 30643357 DOI: 10.3748/wjg.v25.i1.42]

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