Translational pancreatic cancer research: A comparative study on patient-derived xenograft models

Table 2 Impact of clinical characteristics on the engraftment of the first generation (F1) xenograft in mice n (%)

Variables	Number of patients	Number of F1 tumours produced	Impact of clinical characteristics on tumour take rate (P1 value)
Age (yr)
< 70	2	0 (0)	0.444
≥ 70	8	5 (62.5)
Gender
Male	5	2 (40)	0.999
Female	5	3 (60)
Histology
ADCP	9	3 (33.3)	0.180
Ampulloma	2	2 (100)
Differentiation
G1	0	0	<0.001
G2 + G3	10	5 (50)
Staging
≤ II (I or II)	7	2 (28.6)	0.160
> II (III or IV)	3	3 (100)
Tumour origin
Head	9	4 (50)	Not available
Tail	1	0 (0)
Body	0	0
Metastases	1	1 (100)
Perineural invasion
Yes	3	1 (33.3)	0.999
No	7	4 (57.1)
Lymph node metastasis
Yes	6	3 (50)	0.999
No	4	2 (50)
Distant metastases
Yes	2	1 (50)	0.999
No	8	4 (50)

¹Statistical analyses were performed using Fisher’s test, with P < 0.05 considered statistically significant.