Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats

doi:10.3748/wjg.v24.i48.5505

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 28, 2018; 24(48): 5505-5524
Published online Dec 28, 2018. doi: 10.3748/wjg.v24.i48.5505

Table 6 Potential biomarkers identified from liver samples

Retention time (min)	Molecular weight(Da)	VIP	Potential biomarker	Formula	Change trend
Retention time (min)	Molecular weight(Da)	VIP	Potential biomarker	Formula	Model-PKRP
ESI-
3.95787	218.103	9.02621	Pantothenic acid	C₉H₁₇NO₅	up
5.52016	203.082	5.17533	L-Tryptophan	C₁₁H₁₂N₂O₂	up
17.9144	303.232	2.67441	Arachidonic acid	C₂₀H₃₂O₂	up
8.18557	241.073	2.08795	Lumichrome	C₁₂H₁₀N₄O₂	down
17.6944	327.233	2.03102	Docosahexaenoic acid	C₂₂H₃₂O₂	down
9.27129	201.112	1.77891	Sebacic acid	C10H18O₄	down
18.1942	279.232	1.75755	Linoleic acid	C₁₈H₃₂O2	up
11.3188	464.302	1.75082	Glycocholic acid	C₂₆H₄₃NO₆	down
13.9455	313.24	1.66517	9,10-DiHOME	C₁₈H₃₄O₄	down
15.9588	319.227	1.58662	16R-HETE	C₂₀H₃₂O₃	up
7.08734	353.234	1.56066	PGE1	C₂₀H₃₄O₅	up
10.8984	227.128	1.45155	Traumatic acid	C₁₂H₂₀O₄	down
2.5168	251.079	1.41613	Deoxyinosine	C₁₀H₁₂N₄O₄	down
11.4285	221.081	1.39399	Apiole	C₁₂H₁₄O₄	down
16.2815	339.199	1.28069	Canrenone	C₂₂H₂₈O₃	down
11.4127	351.219	1.14883	PGE2	C₂₀H₃₂O₅	up
15.6357	343.228	1.0584	Medroxyprogesterone	C₂₂H₃₂O₃	down
19.0468	281.249	1.03242	Ethyl palmitoleate	C₁₈H₃₄O₂	down
ESI+
5.58168	205.097	25.6421	L-Tryptophan	C₁₁H₁₂N₂O₂	up
1.12985	123.055	23.4569	Niacinamide	C₆H₆N₂O	up
3.94534	220.118	15.5283	Pantothenic acid	C₉H₁₇NO₅	down
1.07398	244.092	13.5445	Cytarabine	C₉H₁₃N₃O₅	down
1.65458	182.081	12.3842	L-Tyrosine	C₉H₁₁NO₃	up
0.901697	132.077	8.82297	3-Guanidinopropanoate	C₄H₉N₃O₂	down
0.990524	203.053	8.06945	L-(+)-Gulose	C₆H₁₂O₆	down
2.07851	269.088	7.66822	Inosine	C₁₀H₁₂N₄O₅	down
15.0942	302.305	7.59274	Sphinganine	C₁₈H₃₉NO₂	down
1.48196	153.04	7.19394	Xanthine	C₅H₄N₄O₂	down
6.38205	130.159	6.90221	Octylamine	C₈H₁₉N	down
1.21181	150.058	6.25979	L-Methionine	C₅H₁₁NO₂S	down
0.83538	146.165	6.24439	Spermidine	C₇H₁₉N₃	down
2.90983	285.083	5.64503	Xanthosine	C₁₀H₁₂N₄O₆	down
1.64612	165.055	5.16323	m-Coumaric acid	C₉H₈O₃	down
11.3366	181.122	4.58665	Dihydroactinidiolide	C₁₁H₁₆O₂	down
1.14382	204.123	4.29542	Succinylmonocholine	C₉H₁₇NO₄	down
2.20661	218.139	4.21655	Propionyl-L-carnitine	C₁₀H₁₉NO₄	down
5.73361	114.092	3.42289	ε-Caprolactam	C₆H₁₁NO	down
17.9613	305.248	1.8771	Arachidonic acid	C₂₀H₃₂O₂	up
13.2435	299.201	1.60893	Norethindrone	C₂₀H₂₆O₂	down
11.7171	181.122	1.58994	Dihydroactinidiolide	C₁₁H₁₆O₂	down

VIP: Variable importance in the projection.

Citation: Yang XX, Wei JD, Mu JK, Liu X, Dong JC, Zeng LX, Gu W, Li JP, Yu J. Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats. World J Gastroenterol 2018; 24(48): 5505-5524
URL: https://www.wjgnet.com/1007-9327/full/v24/i48/5505.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i48.5505