Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Figure 4 Protein interaction network showing microRNAs and their predicted gene targets. The protein interaction network (grey lines) shows the interaction between proteins encoded by target genes that are predicted to be regulated by microRNAs (miRNAs). Predicted interactions between miRNAs and target genes are shown by black lines. The dashed black line represents the possible interaction suggested in this study for miR-135b-5p and TNF. Ellipses represent target genes and/or proteins; red triangles represent upregulated miRNAs; green triangles represent downregulated miRNAs. TNF: Tumour necrosis factor; IL: Interleukin; NFKB: Nuclear factor kappa B; TLR: Toll-like receptor.