MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease

Figure 3 MicroRNA-15a negatively regulates cell division cycle 42 expression in Caco-2 cells. Caco-2 cells were transfected with microRNA-15a (miR-15a) mimic lentivirus and its negative controls or miR-15a inhibitor lentivirus and its negative controls. A: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate the relative mRNA expression of miR-15a in different groups; B: qRT-PCR was used to evaluate the relative mRNA expression of cell division cycle 42 in different groups (^aP < 0.05, ^bP < 0.01 vs negative control cells). Cdc42: Cell division cycle 42; miR: MicroRNA; LV: Lentivirus; NC: Negative control.