Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

doi:10.3748/wjg.v24.i43.4950

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2018; 24(43): 4950-4958
Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4950

Table 1 Clinical characteristics of the patients

Characteristic	CRCIS (n = 114)	CRC (n = 114)	P value
Age	65.33 ± 12.45	63.67 ± 9.18	0.748^a
Gender
Male, n (%)	78 (68.42)	78 (68.42)	1.000^b
Female, n (%)	36 (31.58)	36 (31.58)
Blood tests
WBC (10⁹/L)	7.71 ± 2.27	7.18 ± 1.97	0.058^a
HGB (g/L)	114.96 ± 23.09	122.57 ± 85.55	0.360^a
PLT (10⁹/L)	242.28 ± 116.46	235.51 ± 82.35	0.613^a
NC (10⁹/L)	5.65 ± 2.28	4.16 ± 1.49	< 0.001^a
PT (s)	10.94 ± 1.40	10.82 ± 0.98	0.474^a
INR	0.95 ± 0.13	0.92 ± 0.08	0.137^a
APTT (s)	29.52 ± 6.79	30.11 ± 6.20	0.496^a
FIB (g/L)	5.42 ± 4.42	5.32 ± 4.74	0.862^a
D-dimer (μg/mL)	1.40 ± 0.93	0.56 ± 0.47	< 0.001^a
CRP (mg/L)	33.54 ± 35.50	28.79 ± 34.38	0.431^a
CEA (U/mL)	222.31 ± 175.85	88.48 ± 55.04	< 0.001^a
CA125 (U/mL)	47.13 ± 54.32	22.70 ± 34.61	< 0.001^a
CA199 (U/mL)	293.41 ± 1428.18	24.83 ± 34.212	0.066^a
Type of CRC
Adenocarcinoma	107	110	0.235^b
Nonadenocarcinoma	7	4
Systemic metastasis, n (%)			0.080^b
Yes	74 (64.9)	61 (53.5)
No	40 (35.1)	53 (46.5)
Methods of therapy, n (%)
Surgery	76 (66.7)	87 (76.3)	0.107^b
Chemotherapy	46 (40.4)	33 (28.9)	0.070^b
No treatment	28 (24.6)	24 (21.2)	0.528^b

^aWith two independent samples t-test;

^bWith chi-square test. CRCIS: Colorectal cancer related-ischemic stroke; CRC: Colorectal cancer; WBC: White blood cell; HGB: Hemoglobin; PLT: Platelet; NC: Neutrophil count; PT: Prothrombin time; INR: International normalized ratio; APTT: Activated partial thromboplastin time; FIB: Fibrinogen; CRP: C-reactive protein; CEA: Carcinoembryonic antigen; CA: Cancer antigen.

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Citation: Qin QX, Cheng XM, Lu LZ, Wei YF, Wang DC, Li HH, Li GH, Liang HB, Li SY, Chen L, Liang ZJ. Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke. World J Gastroenterol 2018; 24(43): 4950-4958
URL: https://www.wjgnet.com/1007-9327/full/v24/i43/4950.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i43.4950

Qin QX, Cheng XM, Lu LZ, Wei YF, Wang DC, Li HH, Li GH, Liang HB, Li SY, Chen L, Liang ZJ. Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke. World J Gastroenterol 2018; 24(43): 4950-4958 [PMID: 30487704 DOI: 10.3748/wjg.v24.i43.4950]

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