Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations

Table 2 Simplified scheme of the expression profiles of 7 of 45 markers that showed a statistically significant difference in expression between the juxtatumoural stroma and peripheral stroma

	Fibroblast markers							ECM marker
	α-SMA	CD10	CD271	Cytoglobin	DOG1	miR-21	Nestin	Tenascin C
Juxtatumoural stroma	++++	+++	+	+++	++	+++	++	++++
Peripheral stroma	++++	+	+++	+	-	+	+	+
Lobular stroma	++++	++	+++	+++	+	+	++	++
Septal stroma	++++	+	+++	++	+	+	+	+
Expression in other cells in PC
Adenocarcinoma cells	-	-	-	-	+	++	-	-
Axons	-	-	-	-	-	-	-	-
Endothelial cells	-	-	-	-	-	-	+++	-
Histiocytes	-	-	-	-	-	-	-	-
Mast cells	-	-	-	-	-	-	-	-
Media myocytes	++++	-	+++	-	-	-	-	-
Neutrophilic granulocytes	-	++	-	-	-	-	-	-
Lymphocytes	-	+++	-	-	-	-	-	-

The expression of these markers in the juxtatumoural, peripheral, lobular and septal stroma is shown, as well as that in adenocarcinoma cells, axons, endothelial cells, histiocytes, mast cells, media myocytes, neutrophilic granulocytes, and lymphocytes. Symbol key: (-) Not expressed in the cell type; (+) barely perceptible expression; (++) weak expression; (+++) moderate expression; (++++) strong expression. α-SMA: α-smooth muscle actin; DOG1: Discovered on gastrointestinal stromal tumours 1; ECM: Extracellular matrix; PC: Pancreatic cancer.