Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

Figure 3 Kaplan-Meier survival plots for overall survival and relapse-free survival according to heparanase expression and Helicobacter pylori infection status. A: Heparanase (HPA) expression status (negative or positive) and the prognosis of all gastric cancer cases. HPA positive staining includes all cases of 1+, 2+, and 3+. HPA positive expression detected by immunohistochemical staining significantly predicts poor overall survival and relatively poor relapse-free survival; B: Kaplan-Meier survival according to HPA status in Helicobacter pylori positive gastric cancer cases. HPA positive expression significantly predicts poor overall survival as well as relapse-free survival. HPA: Heparanase; H. pylori: Helicobacter pylori.