Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines

Figure 3 Effect of thiopurine on white blood cell count. A: Absolute number of WBC counts in three groups (Groups A + B vs C vs D) without PSL. We next divided cases into 3 categories: Group A + B, Group C and Group D. Group C was already reported cases with NUDT15 c.415C>T in exon 3 in IBD cases. Group A + B included mutations in exon 1 which is not investigated in IBD. Group A + B and Group C was lower in WBC count and decrease rate than Group D; B: Decrease ratio of WBC counts in three groups (Groups A + B vs C vs D) without PSL; Group A + B and Group C was lower in WBC count and decrease rate than Group D; Group A + B and Group C was lower in decrease rate than Group D. PSL: Prednisolone; WBC: White blood cell; IBD: Inflammatory bowel disease.