Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

Table 2 Interaction between polymorphisms in the genes GSTP1, GSTT1, and GSTM1 and smoking or alcohol habits on the risk of sporadic colorectal cancer

	Tobacco consumption						Alcohol consumption
	Non-smoker			Smoker			Non-smoker			Smoker
	Case	Control	OR1 (95%CI)	Case	Control	OR1 (95%CI)	Case	Control	OR1 (95%CI)	Case	Control	OR1 (95%CI)
GSTP1
A/A	50	136	1.00	57	91	2.33 (1.34-4.05)a	59	116	1.00	48	111	1.31 (0.74-2.31)
A/G-G/G	80	177	1.40 (0.87-2.27)	45	115	1.59 (0.91-2.77)	73	147	1.12 (0.69-1.81)	52	145	1.19 (0.70-2.04)
GSTT1
+/+	110	362	1.00	82	211	1.42 (0.98-2.08)	108	300	1.00	84	273	0.76 (0.52-1.12)
0/0	20	103	0.60 (0.34-1.04)	20	62	1.03 (0.57-1.88)	24	95	0.63 (0.37-1.07)	16	70	0.53 (0.28-1.01)
GSTM1
+/+	52	231	1.00	48	154	1.40 (0.86-2.28)	56	206	1.00	44	179	0.76 (0.46-1.26)
0/0	78	234	1.38 (0.90-2.10)	54	119	2.19 (1.34-3.57)	76	189	1.42 (0.93-2.18)	56	164	1.14 (0.72-1.82)

¹OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;

^aP < 0.05 vs control. OR: Odds ratio.