Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

doi:10.3748/wjg.v24.i38.4356

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2018; 24(38): 4356-4368
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4356

Table 4 Pairwise comparisons between groups are determined according to Dunn[35]

		eNOS	iNOS	PDE5	sGCa1	sGCb1	cGMP
CON vs FIB	sig. (pairwise)	0.024¹	-	0.002¹	0.065	0.006¹	0.151
CON vs FIB	sig. (adjusted)	0.072	-	0.006¹	0.195	0.018¹	0.453
CON vs CIR	sig. (pairwise)	0.001¹	-	0.001¹	0.001¹	0.001¹	0.018¹
CON vs CIR	sig. (adjusted)	0.003¹	-	0.003¹	0.003¹	0.003¹	0.054
FIB vs CIR	sig. (pairwise)	0.280	0.732	0.201	0.194	0.267	0.495
FIB vs CIR	sig. (adjusted)	0.840	1.000	0.603	0.582	0.801	1.000
CON vs CON + Sil	sig. (pairwise)	n.m.²	n.m.²	n.m.²	n.m.²	n.m.²	0.012¹
CON vs CON + Sil	sig. (adjusted)	n.m.²	n.m.²	n.m.²	n.m.²	n.m.²	0.024¹
CIR vs CIR + Sil	sig. (pairwise)	n.m.²	n.m.²	n.m.²	n.m.²	n.m.²	0.009¹
CIR vs CIR + Sil	sig. (adjusted)	n.m.²	n.m.²	n.m.²	n.m.²	n.m.²	0.018¹

¹Significant differences (P < 0.05) are marked by an.

²Means: Not measured.

Adjusted comparisons are corrected according to Bonferroni.

Citation: Schaffner D, Lazaro A, Deibert P, Hasselblatt P, Stoll P, Fauth L, Baumstark MW, Merfort I, Schmitt-Graeff A, Kreisel W. Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension. World J Gastroenterol 2018; 24(38): 4356-4368
URL: https://www.wjgnet.com/1007-9327/full/v24/i38/4356.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i38.4356