Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

Table 5 Diagnostic performance of shear wave elastography for detecting clinically significant portal hypertension (HVPG ≥ 10 mmHg)

Ref.	Year	Patients (n)	Study design	Prevalence (%)	Site	Success rate (%)	Cutoffs (kPa)	AUROC	Se (%)	Sp (%)	PPV (%)	NPV (%)
Procopet et al[64]	2015	88	Restospective	55.0	LS	99.0	17.0	0.859	80.8	82.1
							15.41	0.948	91.3	90.9
					SS	66.0		0.725
Elkrief et al[65]	2015	79	Prospective	90.9	LS	97.0	24.5	0.870	81.0	88.0	98.0	35.0
					SS	97.0	34.7	0.640	40.0	100.0	100.0	18.0
Kim et al[66]	2015	92	Prospective	83.7	LS	98.3	15.2	0.819	85.7	80.0	95.7	52.2
							21.62	0.867	83.3	80.8	91.7	65.6
Jansen et al[67]	2017	109	Prospective multicenter	67.9	LS	100.0	24.6	0.860	68.3	80.4	87.7	55.4
					SS	81.2	26.3	0.840	79.7	84.2	90.8	68.0

¹Highly reliable and reliable measurements (n = 45): SD/median > 0.10 or depth ≥ 5.6 cm;

²Severe portal hypertension (HVPG ≥ 12 mmHg). AUROC: Area under ROC curve; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; LS: Liver stiffness; SS: Spleen stiffness.