Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

Table 3 Diagnostic performance of shear wave elastography for significant fibrosis (F ≥ 2), advanced fibrosis (F ≥ 3) and cirrhosis (F4) in patients with chronic hepatitis B

Ref.	Year	Patients (n)	F ≥ 2 (%)	F ≥ 3 (%)	F = 4 (%)	AUROC	Cutoffs (kPa)	Se (%)	Sp (%)	PPV (%)	NPV (%)
Leung et al[14]	2013	226	60.2			0.880	7.100	84.70	92.10	85.3	91.7
				35.4		0.930	7.900	89.80	90.30	71.8	97.0
					15.5	0.980	10.100	97.40	93.00	60.1	99.6
Zeng et al[54]1	2014	206 (104)	45.7 (45.1)			0.917 (0.907)	7.200	86.36 (85.19)	86.96 (80.85)	88.8 (83.6)	84.2 (82.6)
				69.0 (70.1)		0.945 (0.934)	9.100	91.94 (89.66)	85.71 (80.56)	74.0 (65.0)	96.0 (95.1)
					81.1 (83.7)	0.945 (0.967)	11.700	91.89 (88.24)	89.70 (88.10)	66.7 (60.0)	98.0 (97.4)
Wu et al[53]	2016	437	47.2			0.903	8.200	78.16	85.28	82.6	81.4
					14.0	0.926	11.256	91.80	84.31	48.7	98.4
Zhuang et al[55]1	2017	304(155)	86.8 (84.6)			0.970 (0.970)	7.600	92.00 (91.6)	90.00 (87.5)	98.4 (96.0)	64.3 (65.0)
				70.4 (67.8)		0.960 (0.970)	9.200	91.60 (88.6)	96.70 (96.0)	98.5 (97.8)	82.9 (80.1)
					54.9 (48.4)	0.980 (0.980)	10.400	94.60 (92.0)	94.90 (95.0)	95.7 (94.5)	93.5 (92.7)
Zeng et al[52]	2017	257	46.3			0.882	7.100	88.89	76.38	76.2	89.0
				24.9		0.917	8.300	89.66	76.84	55.9	95.8
					13.2	0.926	11.300	93.55	87.25	52.7	98.9
Herrmann et al[49]	2018	379	52.0			0.906	7.100	87.60	73.60
				29.8		0.931	8.100	94.90	73.10
					13.0	0.955	11.500	79.90	93.90

¹These studies are divided into index cohort and validation cohort and parentheses are index cohort. AUROC: Area under ROC curve; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.