Metabolomic alterations and chromosomal instability status in gastric cancer

Table 3 Altered genes in patients with gastric cancer

	Patients (%)	Alteration gene
All	53	TP53
	47	JAK2, PSIP1, PTPRO
	37	ARID1A, CDH20, CDKN2A, DCC,ITGB2, MALT1, SYNE1, KMT2C
	32	AFF1, CDH1, CDH11, CDH2, CDH5, CDKN2B, LRP1B, MBD1, MMP2, SMAD2, SMAD4, ZNF521
	26	AKAP9, APC, ATM, BCL2, CYLD, EP400, ERG, FANCA, FN1, IL2, LTF, MAF, MTOR, PBRM1, RUNX1, SAMD9, SMARCA4, TAF1L, TCF12, TLR4, TNK2
	< 21	364 genes
CIN tumor	100	JAK2, PSIP1, PTPRD
	78	CDH20, CDKN2A, DCC, MALT1
	67	TP53, AFF1, CDH1, CDH11, CDH2, CDH5, CDKN2B, MBD1, MMP2, SMAD2
	56	ITGB2, ZNF521, ATM, BCL2, CYLD, ERG, FANCA, IL2, MAF, MTOR, PBRM1, RUNX1, TCF12, TLR4
	44	43 genes
	33	70 genes
	< 22	265 genes
Non-CIN tumor	> 50	None
	40	TP53, SYNE1
	30	ARID1A
	20	ITGB2, KMT2C, LRP1B, AKAP9, SAMD9, SMARCA4, TNK2, RNF213, EPHB6, ERBB3
	10	50 genes
	0	346 genes

GC: Gastric cancer; CIN: Chromosomal instability.