Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

Table 4 Results of genome-wide association studies for hepatitis B virus-related advanced liver diseases

Ref.	Study population	Participant phenotypes	SNPID	Minor/major alleles	Risk allele	P	OR	Location	Nearestgene	Functional class
Al-Qahtani et al[85]	Saudi Arabian (n = 693)	LC/HCC vs Inactive1	rs2724432	T/C	T	4.29 × 10-08	3.01	11q22.3	FDX1	Intergenic
Zhang et al[88]	Chinese (n = 4107)	HCC vs Non-HCC2	rs17401966	G/A	A	3.40 × 10-19	0.62	1p36.22	KIF1B	Intron
Chan et al[91]	Chinese (n = 1420)	HCC vs Non-HCC2	rs12682266	A/G	G	3.76 × 10-05	1.38	8p12	Expressed sequenced tag	Intergenic
Li et al[89]	Chinese (n = 12159)	HCC vs Non-HCC2	rs9272105	A/G	A	5.24 × 10-22	1.28	6p21.32	HLA-DQA1, HLA-DRB1	Intergenic
			rs455804	A/C	C	5.24 × 10-10	0.84	21q21.3	GRIK1	Intron
Jiang et al[90]	Chinese (n = 11799)	HCC vs Non-HCC2	rs7574865	T/G	G	2.48 × 10-10	1.21	2q32.2-2q32.3	STAT4	Intron
			rs9275319	G/A	A	2.72 × 10-17	1.49	6p21.32	HLA-DQB1, HLA-DQA2	Intergenic
Tan et al[86]	Chinese (n = 3387)	ACLF vs Inactive3	rs3129859	C/G	C	2.64 × 10-20	1.83	6p21.32	HLA-DQB1, HLA-DRA	Intergenic

¹HBV carriers with LC or HCC vs inactive chronic carriers;

²Chronic HBV carriers with HCC vs chronic HBV carriers without HCC;

³Acute-on-chronic liver failure vs inactive chronic HBV carriers. LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus.