Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

Table 3 Results of genome-wide association studies for non-response to hepatitis B vaccine

Ref.	Study population	SNPID	Minor/major alleles	Riskallele	P	OR	Location	Nearest gene	Functional class
Png et al[73]	Indonesian (n = 3614)1	rs3135363	C/T	C	6.53 × 10-22	1.53	6p21.32	BTNL2, HLA-DRA	Intergenic
		rs9277535	A/G	G	2.91 × 10-12	0.72	6p21.32	HLA-DPB1	3'UTR
		rs9267665	T/C	T	1.24 × 10-17	2.05	6p21.33	STK19	Intron
Pan et al[76]	Chinese (n = 1944)2	rs477515	T/C	T	2.63 × 10-19	2.05	6p21.32	HLA-DRB1	Intergenic
Wu et al[81]	Taiwanese (n = 285)3	rs7770370	A/G	G	1.20 × 10-08	0.33	6p21.32	HLA-DPB1	Intergenic

Participant phenotypes:

¹Low, intermediate and high responders to primary vaccine (ordinal groups);

²High responders to primary vaccine vs non-responders to booster vaccine;

³Non-responders vs responders to booster vaccine.