Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

Table 2 Human leukocyte antigen classical alleles associated with hepatitis B virus persistence in more than one study

HLA gene	Associated alleles	Effect on HBV persistence	Study population	Ref.
HLA-C	*07:02	Protective	Chinese	[24,28,29]
HLA-DPA1	*01:03	Protective	Japanese, Korean, Chinese, Thai	[22,24,58]
	*02:02	Susceptible	Japanese, Korean, Chinese	[22,24,58]
HLA-DPB1	*04:01	Protective	Japanese, Chinese	[22,28,58]
	*04:02	Protective	Japanese, Korean	[22,58]
	*02:01	Protective	Chinese, Japanese	[28,58]
	*05:01	Susceptible	Japanese, Korean, Chinese	[22,24,58,59]
	*09:01	Susceptible	Japanese, Chinese	[22,24,58,59]
HLA-DQA1	*06:01	Susceptible	Chinese	[24,28,30]
HLA-DQB1	*03:02	Protective	Japanese, Chinese	[24,28,30,59]
	*03:01	Susceptible	African American, Chinese	[18,28,30]
	*06:01	Susceptible	Japanese	[23,59]
HLA-DRB1	*13:02	Protective	Japanese, Chinese, Gambian, Korean, Germany, European Americans	[24,59,68]