Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

Table 1 Results of genome-wide association studies for persistence of hepatitis B virus infection

Ref.	Studypopulation	SNPID	Minor/major alleles	Riskallele	P	OR	Location	Nearestgene	Functional class
Kamatani et al[22]	Japanese, Thai (n = 6387)1	rs3077	A/G	G	2.31 × 10-38	0.56	6p21.32	HLA-DPA1	3'UTR
		rs9277535	A/G	G	6.34 × 10-39	0.57	6p21.32	HLA-DPB1	3'UTR
Mbarek et al[23]	Japanese (n = 9163)1	rs3077	A/G	G	1.57 × 10-61	1.87	6p21.32	HLA-DPA1	3'UTR
		rs9277535	A/G	G	2.55 × 10-54	1.77	6p21.32	HLA-DPB1	3'UTR
		rs2856718	A/G	A	3.99 × 10-37	1.56	6p21.32	HLA-DQB1, HLA-DQA2	Intergenic
		rs7453920	A/G	G	5.98 × 10-28	1.81	6p21.32	HLA-DQB2	Intron
Nishida et al[25]	Japanese (n = 1793)2	rs3077	A/G	G	4.40 × 10-19	0.46	6p21.32	HLA-DPA1	3'UTR
		rs9277542	A/G	G	1.28 × 10-15	0.5	6p21.32	HLA-DPB1	Exon
Kim et al[26]	Korean (n = 4309)2	rs3077	A/G	G	3.74 × 10-40	0.53	6p21.32	HLA-DPA1	3'UTR
		rs9277535	A/G	G	5.25 × 10-39	0.53	6p21.32	HLA-DPB1	3'UTR
		rs2856718	A/G	A	1.78 × 10-24	1.6	6p21.32	HLA-DQB1, HLA-DQA2	Intergenic
		rs7453920	A/G	G	6.71 × 10-26	0.5	6p21.32	HLA-DQB2	Intron
		rs652888	G/A	G	7.07 × 10-13	1.38	6p21.33	EHMT2	Intron
		rs1419881	G/A	A	1.26 × 10-18	0.73	6p21.33	TCF19	3'UTR
Hu et al[28]	Chinese (n = 11791)3	rs7453920	A/G	G	4.93 × 10-37	0.53	6p21.32	HLA-DQB2	Intron
		rs3130542	A/G	A	9.49 × 10-14	1.33	6p21.33	HLA-C	Intergenic
		rs4821116	A/G	G	1.71 × 10-12	0.82	22q11.21	UBE2L3	Intron
		rs3077	A/G	G	6.50 × 10-14	0.75	6p21.32	HLA-DPA1	3'UTR
Chang et al[27]	Han Taiwanese (n = 2688)2	rs9277535	A/G	G	4.87 × 10-14	1.59	6p21.32	HLA-DPB1	3'UTR
		rs7453920	A/G	G	6.66 × 10-15	2.31	6p21.32	HLA-DQB2	Intron
Jiang et al[29]	Chinese (n = 18371)1	rs12614	T/C	C	1.28 × 10-34	1.89	6p21.33	CFB	Exon
		rs422951	G/A	A	5.33 × 10-16	1.27	6p21.32	NOTCH4	Exon
		rs378352	T/C	T	1.04 × 10-23	1.26	6p21.32	HLA-DOA	Exon
		rs2853953	A/G	G	5.06 × 10-20	1.47	6p21.33	HLA-C	Intergenic
		rs1883832	T/C	T	2.95 × 10-15	1.19	20q13.12	CD40	5'UTR
		rs2856718	G/A	A	7.35 × 10-28	1.28	6p21.32	HLA-DQB1, HLA-DQA2	Intergenic
		rs7453920	A/G	G	1.28 × 10-60	2	6p21.32	HLA-DQB2	Intron
		rs9277535	A/G	G	9.84 × 10-71	1.52	6p21.32	HLA-DPB1	3'UTR
		rs3077	A/G	G	1.15 × 10-53	1.45	6p21.32	HLA-DPA1	3'UTR
Li et al[30]	Chinese (n = 9569)3	rs7000921	C/T	T	3.20 × 10-12	0.78	8p21.3	INTS10	Intergenic
		rs7453920	A/G	G			6p21.32	HLA-DQB2	Intron
		rs9277535	A/G	G			6p21.32	HLA-DPB1	3'UTR

Participant phenotypes:

¹CHB vs Non-infected;

²Chronic HBV carriers vs Non-infected;

³Chronic HBV carriers vs Spontaneously recovered. OR: Odds ratio.