circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

doi:10.3748/wjg.v24.i3.323

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Jan 21, 2018 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2018; 24(3): 323-337
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.323

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Figure 5 Schematic representation exhibits the circRNA_0046366/miR-34a/PPARα axis underlying occurrence and resolution of hepatocellular steatosis. In contrast to the hepatic steatogenesis that occurs upon its deficiency, circRNA_0046366 restoration abrogates the inhibitory effect of miR-34a on PPARα by antagonizing the miRNA-mRNA interaction. PPARα normalization transcriptionally activates the lipometabolic genes, which further ameliorates hepatic steatosis by regaining lipid homeostasis. mi: Micro; PPAR: Peroxisome proliferator-activated receptor.

Citation: Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337
URL: https://www.wjgnet.com/1007-9327/full/v24/i3/323.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i3.323