Copyright
©The Author(s) 2018.
World J Gastroenterol. Jan 21, 2018; 24(3): 323-337
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.323
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.323
Figure 4 PPARα normalization improved hepatocellular steatosis by transcriptional promotion of lipometabolic genes.
A: PPARα restoration by circRNA-0046366 promoted expression of CPT1A and SLC27A at the transcriptional level; B: Transcriptional activation of CPT1A and SLC27A resulted in their significant up-regulation. Improved expression of lipometabolic genes reduced the TG level (C) and attenuated hepatocellular steatosis (D) (200 ×). Results are expressed as mean ± SD. aP < 0.05, bP < 0.01. PPAR: Peroxisome proliferator-activated receptor; TG: Triglyceride.
- Citation: Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337
- URL: https://www.wjgnet.com/1007-9327/full/v24/i3/323.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i3.323