circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

Figure 3 circRNA_0046366 restoration rescued PPARα expression by miR-34a inactivation. A: Metabolic pathway (hsa01100) was the top-enriched pathway that was affected by circRNA_0046366-induced miR-34a antagonism; B: PPARα mediated the regulatory role of miR-34a in lipid metabolism signaling by controlling expression of multiple lipometabolic genes (adapted from the KEGG database). miR-34a inactivation leads to the up-regulated expression of PPARα at transcriptional (C) and translational (D) levels. Results are expressed as mean ± SD. ^bP < 0.01. KEGG: Kyoto Encyclopedia of Genes and Genomes; PPAR: Peroxisome proliferator-activated receptor.