circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

Figure 2 circRNA_0046366 functions as the antagonist of miR-34a. A: Set intersection filters circRNA_0046366-targeting miRNAs associated with hepatocellular steatosis; B: circRNA-miRNA interaction recognized by the base complementation between MRE of circRNA_0046366 and seed sequence of miR-34a; C: Dual-luciferase reporter assay verified the antagonistic effect of circRNA_0046366 on miR-34a; D: Treatment of circRNA-carrying vector normalized expression level of circRNA_0046366 with counteracting impact on miR-34a; E: Results are expressed as mean ± SD. ^bP < 0.01.