circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

Figure 1 circRNA_0046366 loss demonstrates the epigenetic characteristic of FFA-induced hepatocellular steatosis. A: Oil Red O staining identified HepG2 cells with (steatosis group) or without (normal group) FFA-induced steatosis (200 ×); B: The steatosis group exhibited significant up-regulation of TG content; C: circRNA_0046366 quantification revealed inhibition of its expression after hepatocellular steatosis; D: circRNA_0046366 expression was inversely correlated with hepatocellular TG level in the steatosis group. Results are expressed as mean ± SD. ^bP < 0.01. FFA: Free fatty acid; TG: Triglyceride.