Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

Table 3 Univariate and multivariate analysis of total fatigue and selected variables in Crohn’s disease (n = 227)

	Univariate B	95%CI	P value	Multivariate B	95%CI	P value
Age	-0.01	-0.07, 0.05	0.75	0.00	-0.06, 0.05	0.84
Sex (ref. male)	1.30	-0.16, 2.75	0.08	0.63	-0.67, 1.93	0.34
25-OH-D < 50 nmol/L	Ref.
25-OH-D 50-75	-1.04	-2.79, 0.63	0.22
25-OH-D > 75	-0.66	-2.79, 1.48	0.55
HBI ≥ 5	4.17	2.81, 5.54	< 0.01	3.26	1.92, 4.59	< 0.01
CRP ≥ 5 mg/L	0.68	-0.89, 2.25	0.40
Calprotectin ≥ 100 mg/kg	0.00	1.61, 1.61	1.00
Depressive symptoms1	5.99	4.02, 7.94	< 0.01	4.72	2.82, 6.63	< 0.01
Sleep disturbance	4.04	2.10, 5.99	< 0.01	2.21	0.40, 4.03	0.02

¹HADS-D: Hospital Anxiety and depression score - depression subscore ≥ 8. CD: Crohn’s disease; SCCAI: Simple Clinical Colitis Activity Index; CRP: C-reactive protein; B: Regression coefficient.