Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells

Figure 3 Evaluation of the local pancreatic inflammation during autoimmune pancreatitis. Representative images of T-helper cells (CD3⁺CD4⁺cells) (A); and cytotoxic T-cells (CD3⁺CD8⁺ cells) (B); hyperglycemia induced by STZ decreased the number of T-lymphocytes (defined as number of CD3⁺ per field) (C); little differences are observed in the percentage of cytotoxic T-lymphocytes (CD8⁺CD3⁺ cells × 100 divided by the number of CD3⁺cells) (D); T-helper cells (CD4⁺CD3⁺ cells × 100 divided by the number of CD3⁺cells) (E); and regulatory T-cells (FoxP3⁺CD4⁺cells × 100 divided by the number of CD4⁺ cells) (F). The number of animals evaluated was n = 19 (Sham) and n = 17 (STZ). Differences between the indicated cohorts are indicated as tendency, ^aP = 0.053. STZ: Streptozotocin-treated.