Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib

Table 3 Univariate and multivariate analyses of predictive factors for overall survival

	Univariate analysis		Multivariate analysis
	HR	P value	HR	P value	95%CI
Age (≥ 65 yr)	0.494	0.079
Initial dose (800 mg)	1.635	0.182
Early AFP response	0.834	0.622
AFP (< 100 ng/dL)	0.756	0.450
DCP (< 1000 mAU/mL)	0.806	0.554
MKI-associated HFSR	0.224	< 0.001	0.241	0.001	0.102-0.567
BCLC B	0.358	0.013	0.404	0.041	0.170-0.964
Hypertension	0.889	0.756
Diarrhea	0.950	0.911
Anorexia	1.671	0.162
Alopecia	0.560	0.177

Early alpha-fetoprotein (AFP) response refers to a ≥ 20% improvement in AFP levels within 2 mo. BCLC: Barcelona Clinic Liver Cancer; DCP: Des-gamma-carboxy prothrombin; MKI-associated HFSR: Multikinase inhibitor-associated hand-foot skin reaction.